[1]张来福 尹云厚*.脂滴的生物物理学和细胞生物学研究[J].现代农业研究,2019,(11):90-93.
　Zhang Laifu Yin Yunhou *.Biophysics and cell biology of lipid droplets[J].Modern Agricultural Research,2019,(11):90-93.
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脂滴的生物物理学和细胞生物学研究
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《现代农业研究》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2019年11期
页码:
90-93
栏目:
生物科学
出版日期:
2019-11-04

文章信息/Info

Title:
Biophysics and cell biology of lipid droplets
作者:
张来福 尹云厚*
延边大学133002
Author(s):
Zhang Laifu Yin Yunhou *
Yanbian university 133002
关键词:
脂滴; 生物物理学; 细胞生物学
Keywords:
lipid drops;  biophysics;  cell biology
摘要:
最早对脂滴的研究可以追溯到19 世纪，Richard Altmann 和E.B. Wilson 都描述了细胞 中的脂肪滴，并推测了它们的起源(Altmann, 1890;威尔逊,1896)。早期，脂滴的高衍射特性为其 鉴定提供了便利的光学条件。20 世纪初，由于它们被认为是大多数细胞的组成部分，这种细胞 器被称为脂质体。然而，在20 世纪60 年代末，人造脂质体被发明出来，并很快取代了这个名 字。从那时起，这种细胞器被有过许多名称，包括脂滴、脂体、脂体、脂滴和脂质体。在植物中， 它们通常被称为油体。随着这一领域的迅速发展，它似乎已经定名为“脂滴”。几十年来，除了 形态学研究，脂滴的其他方面几乎没有受到关注。1991 年，脂肪细胞中与脂滴相关的磷酸蛋白 perilipin 的发现，引起人们对这种细胞器的新关注。从那时起，关于脂滴的论文数量急剧增加， 关于脂滴的功能也逐渐被重视起来。
Abstract:
The earliest study of fat droplets can be traced back to the 19th century, when Richard Alt? mann and E.B. Wilson both described fat droplets in cells and speculated on their origin (Altmann, 1890; Wilson,1896). In the early stage, the high diffraction characteristics of lipid droplets provided convenient optical conditions for identification. At the beginning of the 20th century, these organelles were called liposomes because they were thought to be part of most cells. However, artificial liposomes were invented in the late 1960s and soon replaced the name. Since then, the organelle has been given many names, including lipid droplet, lipid body, lipid body, lipid droplet and liposome. In plants, they are often called oil bodies. With the rapid development of this field, it seems to have been named "lipid droplet". For decades, little attention has been paid to other aspects of lipid droplets other than morpho? logical studies. The discovery of perilipin, a phosphate protein associated with lipid droplets, in fat cells in 1991 led to new interest in the organelle. Since then, the number of papers on lipid droplets has in? creased dramatically, and the function of lipid droplets has become increasingly important.

参考文献/References:

[1] Thiam, A. R. et al. COPI buds 60-nm lipid droplets from re constituted water- phospholipid- triacylglyceride interfaces, suggesting a tension clamp function. Proc. Natl Acad. Sci. USA 110,13244-13249 (2013). [2] Chen, Z. & Rand, R. P. The influence of cholesterol on phos pholipid membrane curvature and bending elasticity. Biophys. J. 73, 267-276 (1997). [3] Chernomordik, L. V. & Kozlov, M. M. Protein-lipid interplay in fusion and fission of biological membranes.Annu. Rev. Bio chem. 72, 175-207 (2003). [4] Koestler, D. C. et al. Blood- based profiles of DNA methyla tion predict the underlying distribution of cell types: a valida tion analysis. Epigenetics http://dx.doi. org/10.4161/epi.25430 (2013). [5] Bremond, N., Thiam, A. R. & Bibette, J. Decompressing emulsion droplets favors coalescence. Phys. Rev. Lett. 100, 024501 (2008). [6] Thiam, A. R., Bremond, N. & Bibette, J. Breaking of an emul sion under an ac electric field. Phys. Rev. Lett. 102, 188304 (2009). [7] Bremond, N. & Bibette, J. Exploring emulsion science with microfluidics. Soft Matter 8, 10549-10559(2012). [8] Aarts, D. G., Schmidt, M. & Lekkerkerker, H. N. Direct visual observation of thermal capillary waves. Science 304, 847-850 (2004). [9] Leikin, S., Kozlov, M. M., Fuller, N. L. & Rand, R. P.Mea sured effects of diacylglycerol on structural and elastic proper ties of phospholipid membranes. Biophys. J. 71, 2623- 2632 (1996). [10] De Gennes, P.-G., Brochard-Wyart, F. & Quéré, D. Cap illarity and wetting phenomena: drops, bubbles, pearls, waves (Springer, 2004). [11] Karatekin, E. et al. Cascades of transient pores in giant vesi cles: line tension and transport. Biophys. J.84, 1734- 1749 (2003). [12] Biswas, S., Yin, S. R., Blank, P. S. & Zimmerberg, J.Choles terol promotes hemifusion and pore widening in membrane fusion induced by influenza hemagglutinin. J. Gen. Physiol. 131, 503-513 (2008). [13] Shemesh, T., Luini, A., Malhotra, V., Burger, K. N. & Ko zlov, M. M. Prefission constriction of Golgi tubular carriers driven by local lipid metabolism: a theoretical model. Bio phys. J. 85, 3813-3827 (2003). [14] Fernandez- Ulibarri, I. et al. Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway. Mol. Biol. Cell 18, 3250-3263 (2007).

相似文献/References:

[1]张来福 尹云厚*.细胞脂滴的物理结构及影响其稳定的因素[J].现代农业研究,2019,(10):115.
　Zhang Laifu Yin Yunhou*.The physical structure of cell fat droplets and the factors affecting their stability are summarized[J].Modern Agricultural Research,2019,(11):115.

备注/Memo

备注/Memo:
基金项目：贵州省科技计划项目（黔科合基础[2018]1073） 作者简介：张来福，男，汉族，黑龙江鸡西人，延边大学，硕士，主要从事动物营养方面研究。 尹云厚，男，汉族，江西永新人，贵州民族大学，博士，副教授，主要从事动物营养方面研究。
更新日期/Last Update: 1900-01-01